Protein Crosslinkers, GC Derivatization, Protein Modificaiton, LCMS from CovaChem. Dedicated to Life Science Research.

Articles

Articles

CovaChem's compilation of useful articles is intended to provide some background information on many of CovaChem's great products and provide scientists with some further understanding our products and technology.



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Articles Entries

Sulfo-NHS and NHS Esters in Protein Chemistry
Sulfo-NHS and NHS Esters in Protein Chemistry
Category: Articles
Posted: 02-26-2018 18:43
Synopsis: This article describes the reaction of Sulfo-NHS esters with proteins and peptides in buffered reaction systems.  Several of the key reaction concerns are covered here.  This post is intended to provide some background for protein research scientists before planning experiments involving this class of compounds.
Crosslinking Proteins With DTSSP
Crosslinking Proteins With DTSSP
Category: Articles
Posted: 02-26-2018 08:45
Synopsis: This article describes some of the useful features of the homobifunctional crosslinker 3,3'-Dithiobis(sulfosuccinimidyl propionate), also known as DTSSP.
Fundamentals of Choosing a MALDI Matrix
Fundamentals of Choosing a MALDI Matrix
Category: Articles
Posted: 02-26-2018 07:50
Synopsis: MALDI is a commonly employed technique for analyzing proteins and other biomolecules by mass spectrometry.  This soft ionization technique can be ideal for deciphering the mass and composition of proteins and peptide fragments, but often require some forethought into experimental design.
Liquid Chromatography: Mobile Phases for LCMS
Liquid Chromatography: Mobile Phases for LCMS
Category: Articles
Posted: 02-26-2018 05:49
Synopsis: This article describes some important aspects of selecting the best mobile phase for a specific application.  Posting also covers some of the more common mobile phase additives used in LC/MS.
Beta-Glucuronidase in the Hydrolysis of Glucuronide-Drug Conjugates
Beta-Glucuronidase in the Hydrolysis of Glucuronide-Drug Conjugates
Category: Articles
Posted: 02-25-2018 21:53
Synopsis:

The useful application of Beta-Glucuronidase in hydrolysis of glucuronides.  Organic mechanism of glucuronide conjugate hydrolytic cleavage.