SPDP Crosslinker

  Description Price Buy
SPDP Crosslinker
Package Size: 100 mg
SKU: 13411-100
WEIGHT: 0.20
SPDP Crosslinker
Package Size: 1 gram
SKU: 13411-1
WEIGHT: 0.20

N-succinimidyl-3-(2-pyridyldithio)propionate (SPDP Crosslinker) is a cleavable heterobifunctional crosslinker. SPDP contains a dithiopyridyl group which is reactive towards cyteines (-SH groups) and an NHS group, which is useful when targetting primary amines (-NH2 groups). SPDP also contains a disulfide linkage in its spacer arm, which is cleavable with reducing agent, such as DTT, TCEP, among a few others carried by CovaChem.

Package Sizes: 100 mg and 1 gram

Product Numbers: 13411-100mg and 13411-1g

Product Name: SPDP Crosslinker

Alternative Names: SPDP; SPDP Crosslinker; 68181-17-9; N-succinimidyl-3-(2-pyridyldithio)propionate; 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester; 3-(2-Pyridyldithio)propionic acid NHS ester; C12H12N2O4S2


Appearance: White Solid

Purity: is ≥ 95% by quantitative NMR

Storage: 4 °C, protected from moisture


Properties Physical State: Solid

CAS#: 68181-17-9

Chemical Formula: C12H12N2O10

Molecular Weight: 312.36

Spacer length: 6.4 Å

Melting Point: 84-86 °C (Lit)

Country of Origin: USA

Tariff Code: 2933.99.7900

Additional Product Information:
SPDP Crosslinker Product Information Bulletin
SPDP Crosslinker MSDS
  • 4-Azidobenzoic acid

    4-azidobenzoic acid is a heterobifunctional crosslinker that contains a carboxy group and a photoreactive phenyl azide group.
  • 4-carbethoxyhexafluorobutyrl chloride (4-CB)

    4-carbethoxyhexafluorobutyrl chloride (4-CB) is an alkylation reagent used in GC derivatization for improved gas chromatographic separations.
  • Biotin-NHS (CAS 35013-72-0)

    NHS-Biotin is a simple, amine reactive biotinylation reagent.
  • Citraconic Anhydride

    Citraconic Anhydride (Methylmaleic anhydride) is used to block primary amine (-NH2) groups at pH 7 to 9. Citraconic anhydride reacts with primary amines to create a reversible amide linkage, which can be reversed under acidic conditions or in the presence of hydroxylamine.
  • DST Crosslinker

    Disuccinimidyl tartrate (DST) is an amine reactive, water soluble, cleavable crosslinker. DST is a homobifunctional crosslinker that is reactive towards amines
  • HPLC Grade Isopropanol

    CovaChem's HPLC Grade Isopropanol (2-Propanol) is a high purity solvent well suited for HPLC applications, chemical synthesis and general laboratory use.
  • Iodoacetamide (IAA)

    Iodoacetamide (IAA)
  • LCMS Grade Ammonium Formate (10 M Solution)

    LCMS Grade Ammonium Formate Solution (10 M Liquid) from CovaChem is of highly refined and ideally suited for sensitive LCMS and HPLC applications.