SMCC Crosslinker

  Description Price Buy
SMCC Crosslinker
Package Size: 100 mg
SKU: 13409-100
WEIGHT: 0.20
SMCC Crosslinker
Package Size: 1 gram
SKU: 13409-1
WEIGHT: 0.20

SMCC is a heterobifunctional protein crosslinker. SMCC is commonly used to prepare antibody-enzyme conjugates. This molecule contains an amine reactive NHS ester on one end, and a maleimide functional group that can be utilized to react specifically with sulfhydryl (-SH) moeities. The maleimide functional group does not readily react with amino group (-NH2) as found on lysine residues, thus maleimide activated conjugates can be readily formed and preserved for later utilization.

Package Sizes: 100 mg and 1 gram

Product Numbers: 13409-100mg and 13409-1g

Product Name: SMCC Crosslinker

Alternative Names: SMCC; SMCC Crosslinker; 64987-85-5; 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester; N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate; C16H18N2O6


Appearance: White Solid

Purity: is ≥ 90% by quantitative NMR

Storage: 4 °C, protected from moisture


Properties Physical State: Solid

CAS#: 64987-85-5

Chemical Formula: C16H18N2O6

Molecular Weight: 334.32

Spacer length: 8.3 Å

Melting Point: 180-182 °C (Lit)

Country of Origin: USA

Tariff Code: 2928.00.5000

Additional Product Information:
SMCC Crosslinker Product Information Bulletin
SMCC Crosslinker MSDS
  • 4-carbethoxyhexafluorobutyrl chloride (4-CB)

    4-carbethoxyhexafluorobutyrl chloride (4-CB) is an alkylation reagent used in GC derivatization for improved gas chromatographic separations.
  • DMSO (Dimethylsulfoxide)

    CovaChem's Molecular Biology Grade DMSO is a high purity solvent intended for use in protein assays, chromatography, and other highly sensitive applications.
  • DSP Crosslinker

    Lomant's reagent (DSP) is a reducible homobifunctional crosslinker. Another common name for this reagent is DTSP. DSP contains two NHS esters and contains a disulfide linkage that is cleavable.
  • EMCS Crosslinker

    N-(∑-Maleimidocaproyloxy) succinimide ester(EMCS) is a heterobifunctional crosslinker with a spacer length of 9.4 Å. EMCS contains an amine reactive, NHS ester, and a maleimide group which is reactive towards sulfhydryl functional groups.
  • LCMS Grade Ammonium Formate

    LCMS Grade Ammonium Formate (CAS# ‎540-69-2) from CovaChem is of Ultra High Purity ideally suited for sensitive LCMS and HPLC applications.
  • LCMS Grade Propionic acid (UltraPure)

    LCMS Grade Propionic acid (Ultra High Purity) from CovaChem is well suited for HPLC and LCMS applications. Propionic acid can be used as a mobile phase for HPLC or LCMS, or can be used post-column in LCMS applications to increase ionization efficiencies when ion pairing agents are used for separation.
  • Maleimide > 99%

    Maleimide (2,5-Pyrroledione) is a five member ringed compound that is commonly used in synthetic applications and as a synthetic starting material for cysteine blocking, Diels-Alder synthesis, and through Michael addition.
  • MBT MALDI Matrix

    MBT MALDI Matrix - Mercaptobenzothiazole