DSG Crosslinker

  Description Price Buy
DSG Crosslinker DSG Crosslinker
Package Sizes: 100 mg
SKU: 13301-100
WEIGHT: 0.20
DSG Crosslinker DSG Crosslinker
Package Sizes: 5 x 100 mg
SKU: 13301-5x100
WEIGHT: 0.20
DSG Crosslinker DSG Crosslinker
Package Sizes: 1 gram
SKU: 13301-1
WEIGHT: 0.20

Disuccinimidyl glutarate (DSG) is a cell membrane permeable, homobifunctional crosslinker with a five carbon spacer arm. DSG contains two NHS esters that are ideal for selectively targeting primary amine moieties at pH 7 to 9. DSG is a simple, short length crosslinker that forms irreversible amide bonds with lysine residues. This compound is ideally suited for a wide range of crosslinking applications, where a cleavable crosslinker is not preferential.

This compound is also available in a water soluble form (BS2G), which enables direct addition to aqueous buffers, when the user prefers not to use any organic solvents in their crosslinking applications.

CovaChem's DSG is among the highest purity in the industry, with an absolute purity specification of ≥ 97%, measured with quantitative NMR against an internal standard, and typical batches have purity values close to 99% pure.

Package Sizes: 100 mg and 1 gram

Product Numbers: 13301-100 and 13301-1

Product Name: DSG Crosslinker

Alternative Names: DSG, discuccinimidyl glutarate, DSG crosslinker, Succinimidyl glutarate, Di(N-succinimidyl) glutarate, 2,5-dioxopyrrolidin-1-yl 6-(2,5-dioxopyrrolidin-1-yl)-5-oxohexanoate; C13H14N2 O8


Appearance: White Solid

Purity: is ≥ 97% by quantitative NMR

Storage: 4 °C, protected from moisture


Properties Physical State: Solid

CAS#: 79642-50-5

Chemical Formula: C13H14N2 O8

Molecular Weight: 326.26

Spacer length: 7.7 Å

Melting Point: 142-145 °C (Lit)

Country of Origin: USA

Tariff Code: 2928.00.5000

Additional Product Information:
DSG Product Information Bulletin
DSG Crosslinker MSDS
  • 4-carbethoxyhexafluorobutyrl chloride (4-CB)

    4-carbethoxyhexafluorobutyrl chloride (4-CB) is an alkylation reagent used in GC derivatization for improved gas chromatographic separations.
  • BS3 Crosslinker

    Bis-sulfosuccinimidyl suberate (BS3) is an amino reactive, homobifunctional crosslinker. BS3 is water soluble and membrane impermeable.

  • DCC (Dicyclohexylcarbodiimide)

    N,N''-Dicyclohexylcarbodiimide (DCC) is a zero length crosslinker. Dicyclohexylcarbodiimide is a coupling reagent used to couple carboxylic acids (COOH) to primary amines (-NH2).
  • DHB MALDI Matrix

    2,5-Dihydroxybenzoic acid (DHB) is a MALDI matrix used in the MALDI-MS of proteins, peptides, synthetic polymers, lipids and carbohydrates.
  • DryBlend PBS (Phosphate Buffered Saline), pH 7.2

    Phosphate buffered saline is used as a buffer in protein crosslinking and protein modification reactions.
  • DSS Crosslinker

    Disuccinimidyl Suberate (DSS) is a homobifunctional crosslinker that reacts with primary amines.
  • GMBS Crosslinker

    4-Maleimidobutyric acid N-hydroxysuccinimide ester (GMBS) is a heterobifunctional crosslinker with a spacer length of 7.4 Å. BMPS contains an amine reactive, NHS ester, and a maleimide group which is reactive towards sulfhydryl functional groups.
  • Heptafluorobutyric anhydride |HFAA | CAS 336-59-4 | HFBA Anhydride

    Heptaflurobutyric anhydride (HFAA) is an acylation reagent used to improve a compounds volatility and introduce fluorine atoms into an analyte compound for improved volatility.
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