DSG Crosslinker

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DSG CrosslinkerDSG Crosslinker
Package Sizes: 100 mg
SKU: 13301-100
WEIGHT: 0.20
$45.00
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DSG CrosslinkerDSG Crosslinker
Package Sizes: 1 gram
SKU: 13301-1
WEIGHT: 0.20
$399.00
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Disuccinimidyl glutarate (DSG) is a cell membrane permeable, homobifunctional crosslinker with a five carbon spacer arm. DSG contains two NHS esters that are ideal for selectively targeting primary amine moieties at pH 7 to 9. DSG is a simple, short length crosslinker that forms irreversible amide bonds with lysine residues. This compound is ideally suited for a wide range of crosslinking applications, where a cleavable crosslinker is not preferential.

This compound is also available in a water soluble form (BS2G), which enables direct addition to aqueous buffers, when the user prefers not to use any organic solvents in their crosslinking applications.

CovaChem's DSG is among the highest purity in the industry, with an absolute purity specification of ≥ 97%, measured with quantitative NMR against an internal standard, and typical batches have purity values close to 99% pure.

Package Sizes: 100 mg and 1 gram

Product Numbers: 13301-100 and 13301-1 (Guaranteed In Stock!)

Product Name: DSG Crosslinker

Alternative Names: DSG, discuccinimidyl glutarate, DSG crosslinker, Succinimidyl glutarate, Di(N-succinimidyl) glutarate, 2,5-dioxopyrrolidin-1-yl 6-(2,5-dioxopyrrolidin-1-yl)-5-oxohexanoate; C13H14N2 O8

Specifications

Appearance: White Solid

Purity: is ≥ 97% by quantitative NMR

Storage: 4 °C, protected from moisture

Properties

Properties Physical State: Solid

CAS#: 79642-50-5

Chemical Formula: C13H14N2 O8

Molecular Weight: 326.26

Spacer length: 7.7 Å

Melting Point: 142-145 °C (Lit)

Country of Origin: USA

Tariff Code: 2928.00.5000


Additional Product Information:
DSG Product Information Bulletin
DSG Crosslinker MSDS
  • 2-Iminothiolane

    2-Iminothiolane

    2-Iminothiolane hydrochloride (Traut's Reagent) is used to convert primary amine (-NH2) groups to sulfhydryl groups (-SH) at pH 7 to 10. Traut's reagent (2-IT) is a water soluble molecule that is easy to use and creates a wide range of flexibility to the researcher.
    $69.00
  • CHCA MALDI Matrix

    CHCA MALDI Matrix

    CHCA MALDI Matrix is a reagent used to create ions for MALDI-MS and MALDI TOF TOF analysis of protein and peptide molecules below 4,000 Daltons. TOF TOF mass spectrometry is one of the more common forms of MALDI-MS/MS, although several other types of mass spectrometers can also be coupled to MALDI instrumentation.
    $30.00
  • DCC (Dicyclohexylcarbodiimide)

    DCC (Dicyclohexylcarbodiimide)

    N,N''-Dicyclohexylcarbodiimide (DCC) is a zero length crosslinker. Dicyclohexylcarbodiimide is a coupling reagent used to couple carboxylic acids (COOH) to primary amines (-NH2).
    $19.00
  • EDC-HCL | EDAC-HCL | > 99%

    EDC-HCL | EDAC-HCL | > 99%

    N-Ethyl-N'(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC-HCl) is a zero length protein crosslinker. Also known as EDAC-HCl, this reagent is often used with either Sulfo-NHS (CovaChem 13505) or NHS (CovaChem 13504). EDC functions by activating the carboxyl region of the protein or other molecule, and coupling it to an amine or other nucleophilic functional group.
    $19.00
  • GMBS Crosslinker

    GMBS Crosslinker

    4-Maleimidobutyric acid N-hydroxysuccinimide ester (GMBS) is a heterobifunctional crosslinker with a spacer length of 7.4 Å. BMPS contains an amine reactive, NHS ester, and a maleimide group which is reactive towards sulfhydryl functional groups.
    $142.00
  • LC-SPDP Crosslinker

    LC-SPDP Crosslinker

    Succinimidyl 6-[3-(2-pyridyldithio)propionamido] hexanoate (LC-SPDP) is a heterobifunctional crosslinker that is amino reactive on one end and sulfhydryl reactive on the other end. LC-SPDP contains a long spacer arm (15.7 Å)for increased molecular flexibility and a reducible disulfide, which is allows for cleavage of the crosslinker after crosslink formation.
    $197.00
  • Molecular Biology Grade Glycine

    Molecular Biology Grade Glycine

    Molecular Biology grade Glycine is frequently used as a component in biological buffers.
    $18.00
  • MSTFA

    MSTFA

    N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a silylation reagent, that donates a trimethylsilyl group to create thermally stable derivatives. MSTFA is reacts with a variety of polar molecules by replacing labile hydrogens. TMCS can be used in addition to MSTFA to form derivatives with hindered hydroxyl groups that won't ordinarily react with MSTFA, secondary amines, and amides.
    $34.00
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