BS3 Crosslinker

  Description Price Buy
BS3 Crosslinker
Package Sizes: 10 x 5 mg
SKU: 13306-10x5
WEIGHT: 0.20
BS3 Crosslinker
Package Sizes: 100 mg
SKU: 13306-100
WEIGHT: 0.20
BS3 Crosslinker
Package Sizes: 1 gram
SKU: 13306-1
WEIGHT: 0.20

Bis-sulfosuccinimidyl suberate (BS3) is a water soluble, non-cleavable, membrane impermeable homobifunctional protein crosslinker. BS3 is homobifunctional protein crosslinker with targeted reactivity towards primary amines at pH 7 to pH 9. Proteins are often a rich source of amines, both in lysine (K) residues and the N-terminus. Once reacted with the amine (-NH2) group, amide bond is formed. 

Package Sizes: 10 x 5 mg, 100 mg and 1 gram

Product Numbers: 13306-10x5, 13306-100 and 13306-1

Product Name: BS3 Crosslinker

Alternative Names: bis-sulfosuccinimidyl suberate; BS3; sulfo-DSS; bis-sulfo-succinimidyl suberate; 82436-77-9; C16H18N2Na2O14S2; bissulfosuccinimidyl suberate; Sulfo-DSS; Suberic acid sulfo-NHS ester; BSSS; BS3-d0; sodium 1,1'-(octanedioylbis(oxy))bis(2,5-dioxopyrrolidine-3-sulfonate), BS3 protein crosslinker


Appearance: White Solid

Purity: is ≥ 90% Storage: 4 °C, protected from moisture


Properties Physical State: Solid

CAS#: 82436-77-9

Chemical Formula: C16H18N2Na2O14S2

Molecular Weight: 572.43

Spacer length: 11.4 Å

Melting Point: >300 °C (Lit)

Country of Origin: USA

Tariff Code: 2925.19.9100

Additional Product Information:
BS3 Product Information Bulletin
BS3 Crosslinker MSDS
  • 2-Iminothiolane


    2-Iminothiolane hydrochloride (Traut's Reagent) is used to convert primary amine (-NH2) groups to sulfhydryl groups (-SH) at pH 7 to 10. Traut's reagent (2-IT) is a water soluble molecule that is easy to use and creates a wide range of flexibility to the researcher.
  • 2-Mercaptoethanol


    2-Mercaptoethanol (2-ME) is a reducing agent used in synthetic and biological applications. This reducing agent is offered in multiple sizes to maximize its efficiency and shelf life. CovaChem's 2-Mercaptoethanol (11301-10 x 1 g) is designed for use in biological assays. These 1 gram hermetically sealed ampules provide maximum protection of the active thiol group and inconsistent activity from use to use or bottle to bottle.
  • 4-carbethoxyhexafluorobutyrl chloride (4-CB)

    4-carbethoxyhexafluorobutyrl chloride (4-CB)

    4-carbethoxyhexafluorobutyrl chloride (4-CB) is an alkylation reagent used in GC derivatization for improved gas chromatographic separations.
  • DHB MALDI Matrix

    DHB MALDI Matrix

    2,5-Dihydroxybenzoic acid (DHB) is a MALDI matrix used in the MALDI-MS of proteins, peptides, synthetic polymers, lipids and carbohydrates.
  • DryBlend PBS (Phosphate Buffered Saline), pH 7.2

    DryBlend PBS (Phosphate Buffered Saline), pH 7.2

    Phosphate buffered saline is used as a buffer in protein crosslinking and protein modification reactions.
  • DST Crosslinker

    DST Crosslinker

    Disuccinimidyl tartrate (DST) is an amine reactive, water soluble, cleavable crosslinker. DST is a homobifunctional crosslinker that is reactive towards amines
  • EGS Crosslinker

    EGS Crosslinker

    Ethylene glycol bis(succininic acid) N-hydroxysuccinimide ester) is a cleavable, homobifuntional crosslinker that contains two NHS functional groups. The NHS functional groups of EGS are selectively reactive towards primary amines at pH 7 to 9. EGS is cleavable with hydroxylamine at pH 8.5. EGS is often used as a cleavable option when disulfide containing crosslinkers, such as DSP (CovaChem 13304) and DTSSP (CovaChem 13303) are not an option due to the desire to retain disulfide networks of a protein intact.
  • HPLC Grade Water

    HPLC Grade Water

    CovaChem's HPLC Grade water is refined for optimal performance in High Performance Liquid Chromatography.
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