EGS Crosslinker

EGS Crosslinker

Description Price Quantity Buy
Package Sizes: 100 mg
SKU: 13308-100
Package Sizes: 1 gram
SKU: 13308-1
Ethylene glycol bis(succininic acid) N-hydroxysuccinimide ester) is a cleavable, homobifuntional crosslinker that contains two NHS functional groups. The NHS functional groups of EGS are selectively reactive towards primary amines at pH 7 to 9. After crosslinking, the EGS spacer arm is cleavable with Hydroxylamine (CovaChem 11304) at pH 8.5. EGS is often used as a cleavable option when disulfide containing crosslinkers, such as DSP (CovaChem 13304 ) and DTSSP (CovaChem 13303) are not an option due to the desire to retain disulfide networks of a protein intact.

Package Sizes: 100 mg and 1 gram

Product Numbers: 13408-100 and 13408-1

Product Name: EGS Crosslinker

Alternative Names: EGS; ethylene glycol bis(succinimidylsuccinate); ethylene glycol di(succinimidylsuccinate); ethylene glycoldisuccinate di(N-succinimidyl) ester; 70539-42-3; Di(N-succinimidyl) ethylene glycol disccuinate; C18H20N2O12


Appearance: White Solid

Purity: is ≥ 90% by quantitative NMR

Storage: 4 °C, protected from moisture


Properties Physical State: Solid

CAS#: 70539-42-3

Chemical Formula: C18H20N2O12

Molecular Weight: 456.36

Spacer length: 16.1 Å

Country of Origin: USA

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Triethylamine (UltraPure)



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