Description Price Buy
Package Size: 500 mg
SKU: 13505-500
WEIGHT: 0.20
Package Size: 1 gram
SKU: 13505-1
WEIGHT: 0.20
Package Size: 5 grams
SKU: 13505-5
WEIGHT: 0.30

N-Hydroxysulfosuccinimide sodium salt (Sulfo-NHS) is used in conjunction with EDC-HCl (CovaChem 13503). Sulfo-NHS is used as a catalyst in the zero-length crosslinking of proteins with EDC. Sulfo-NHS functions by stabilizing the protein-EDC intermediate, thus allowing for a more efficient crosslinking reaction.

Package Sizes: 500 mg, 1 gram, 5 grams

Product Numbers: 13405-500, 13405-1, and 13405-5

Product Name: Sulfo-NHS

Alternative Names: Hydroxy-2,3-dixopyrrolidine-3-sulfonic acid sodium salt; Sulfo-NHS; SNHS; N-Hydroxysulfosuccinimide sodium salt; 106627-54-7; C4H4NNaO6S


Appearance: White Solid

Purity: ≥ 99% by quantitative NMR

Storage: 4 °C, protected from moisture


Properties Physical State: Solid

CAS#: 106627-54-7

Chemical Formula: C4H4NNaO6 S

Molecular Weight: 217.13

Country of Origin: USA

Tariff Code: 2928.00.5000

Additional Product Information:

Sulfo NHS Product Information Bulletin
Sulfo NHS Protein Coupling Protocol
Sulfo NHS Sulfosuccinimide MSDS

  • Citraconic Anhydride

    Citraconic Anhydride

    Citraconic Anhydride (Methylmaleic anhydride) is used to block primary amine (-NH2) groups at pH 7 to 9. Citraconic anhydride reacts with primary amines to create a reversible amide linkage, which can be reversed under acidic conditions or in the presence of hydroxylamine.
  • D-Biotin


    Biotin is a compound used to biotinylate proteins with the addition of a zero length cross linking reagent. D-Biotin has several biology research applications, where the avidin biotin interaction is utilized.
  • DSS Crosslinker

    DSS Crosslinker

    Disuccinimidyl Suberate (DSS) is a homobifunctional crosslinker that reacts with primary amines.
  • EGS Crosslinker

    EGS Crosslinker

    Ethylene glycol bis(succininic acid) N-hydroxysuccinimide ester) is a cleavable, homobifuntional crosslinker that contains two NHS functional groups. The NHS functional groups of EGS are selectively reactive towards primary amines at pH 7 to 9. EGS is cleavable with hydroxylamine at pH 8.5. EGS is often used as a cleavable option when disulfide containing crosslinkers, such as DSP (CovaChem 13304) and DTSSP (CovaChem 13303) are not an option due to the desire to retain disulfide networks of a protein intact.
  • HPLC Grade Isopropanol

    HPLC Grade Isopropanol

    CovaChem's HPLC Grade Isopropanol (2-Propanol) is a high purity solvent well suited for HPLC applications, chemical synthesis and general laboratory use.
  • LC-SPDP Crosslinker

    LC-SPDP Crosslinker

    Succinimidyl 6-[3-(2-pyridyldithio)propionamido] hexanoate (LC-SPDP) is a heterobifunctional crosslinker that is amino reactive on one end and sulfhydryl reactive on the other end. LC-SPDP contains a long spacer arm (15.7 Å)for increased molecular flexibility and a reducible disulfide, which is allows for cleavage of the crosslinker after crosslink formation.
  • LCMS Grade Formic Acid plus TFA (UltraPure)

    LCMS Grade Formic Acid plus TFA (UltraPure)

    LCMS Grade Formic Acid with TFA from CovaChem is of Ultra High Purity ideally suited for sensitive LCMS and HPLC applications. This mixture offers the ability to quickly and easily make one liter of 0.1% Formic Acid with 0.01% TFA enabling the exceptional resolving powers of Trifluoroacetic acid (TFA) without reducing ionization efficiencies.
  • Maleimide > 99%

    Maleimide > 99%

    Maleimide (2,5-Pyrroledione) is a five member ringed compound that is commonly used in synthetic applications and as a synthetic starting material for cysteine blocking, Diels-Alder synthesis, and through Michael addition.
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