Description Price Buy
Package Size: 500 mg
SKU: 13505-500
WEIGHT: 0.20
Package Size: 1 gram
SKU: 13505-1
WEIGHT: 0.20
Package Size: 5 grams
SKU: 13505-5
WEIGHT: 0.30

N-Hydroxysulfosuccinimide sodium salt (Sulfo-NHS) is used in conjunction with EDC-HCl (CovaChem 13503). Sulfo-NHS is used as a catalyst in the zero-length crosslinking of proteins with EDC. Sulfo-NHS functions by stabilizing the protein-EDC intermediate, thus allowing for a more efficient crosslinking reaction.

Package Sizes: 500 mg, 1 gram, 5 grams

Product Numbers: 13405-500, 13405-1, and 13405-5

Product Name: Sulfo-NHS

Alternative Names: Hydroxy-2,3-dixopyrrolidine-3-sulfonic acid sodium salt; Sulfo-NHS; SNHS; N-Hydroxysulfosuccinimide sodium salt; 106627-54-7; C4H4NNaO6S


Appearance: White Solid

Purity: ≥ 99% by quantitative NMR

Storage: 4 °C, protected from moisture


Properties Physical State: Solid

CAS#: 106627-54-7

Chemical Formula: C4H4NNaO6 S

Molecular Weight: 217.13

Country of Origin: USA

Tariff Code: 2928.00.5000

Additional Product Information:

Sulfo NHS Product Information Bulletin
Sulfo NHS Protein Coupling Protocol
Sulfo NHS Sulfosuccinimide MSDS

  • Biotin-Hydrazide

    Biotinylation reagent for carbohydrates. Biotin-Hydrazide
  • BS2G Crosslinker

    BS2G (Sulfo-DSG) is a water soluble amine (amino) reactive homobifunctional crosslinker.
  • Citraconic Anhydride

    Citraconic Anhydride (Methylmaleic anhydride) is used to block primary amine (-NH2) groups at pH 7 to 9. Citraconic anhydride reacts with primary amines to create a reversible amide linkage, which can be reversed under acidic conditions or in the presence of hydroxylamine.
  • D-Biotin

    Biotin is a compound used to biotinylate proteins with the addition of a zero length cross linking reagent. D-Biotin has several biology research applications, where the avidin biotin interaction is utilized.
  • GMBS Crosslinker

    4-Maleimidobutyric acid N-hydroxysuccinimide ester (GMBS) is a heterobifunctional crosslinker with a spacer length of 7.4 Å. BMPS contains an amine reactive, NHS ester, and a maleimide group which is reactive towards sulfhydryl functional groups.
  • Heptafluorobutyric anhydride |HFAA | CAS 336-59-4 | HFBA Anhydride

    Heptaflurobutyric anhydride (HFAA) is an acylation reagent used to improve a compounds volatility and introduce fluorine atoms into an analyte compound for improved volatility.
  • LC-SPDP Crosslinker

    Succinimidyl 6-[3-(2-pyridyldithio)propionamido] hexanoate (LC-SPDP) is a heterobifunctional crosslinker that is amino reactive on one end and sulfhydryl reactive on the other end. LC-SPDP contains a long spacer arm (15.7 Å)for increased molecular flexibility and a reducible disulfide, which is allows for cleavage of the crosslinker after crosslink formation.
  • LCMS Grade Acetonitrile

    CovaChem's LCMS Grade Acetonitrile is a high purity solvent ideally suited for LC/MS and other mass spectrometry related applications.
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