CovaChem's LCMS Grade Formic Acid with TFA from CovaChem is of Ultra High Purity ideally suited for sensitive LCMS and HPLC applications. This mixture offers the ability to quickly and easily make one liter of 0.1% Formic Acid with 0.01% TFA enabling the exceptional resolving powers of Trifluoroacetic acid (TFA) without reducing ionization efficiencies.
LCMS Grade Formic Acid is ideally suited as a chromatography additive for use in LCMS applications, where the ion pairing effects of TFA is needed, but high Mass Spectrometry sensitivity is also required.
CovaChem's LCMS Grade Formic Acid with TFA comes in two convenient package sizes (10 x 1.1 mL Ampules and 25 mL bottles). The 1.1 mL Ampules of LCMS Grade Formic Acid are useful for quickly preparing 1 Liter bottles of 0.1% Formic Acid with 0.01% TFA solutions in either water or other organic solvents.
Package Sizes: 10 x 1.1 mL and 25 mL
Product Numbers: 11207-10x1 or 11207-25
Product Name: LCMS Grade Formic Acid with TFA
Alternative Names: Mixture of Formic Acid and TFA, TFA fix, Formic Acid + TFA
Ethylene glycol bis(succininic acid) N-hydroxysuccinimide ester) is a cleavable, homobifuntional crosslinker that contains two NHS functional groups. The NHS functional groups of EGS are selectively reactive towards primary amines at pH 7 to 9. EGS is cleavable with hydroxylamine at pH 8.5. EGS is often used as a cleavable option when disulfide containing crosslinkers, such as DSP (CovaChem 13304) and DTSSP (CovaChem 13303) are not an option due to the desire to retain disulfide networks of a protein intact.
4-Maleimidobutyric acid N-hydroxysuccinimide ester (GMBS) is a heterobifunctional crosslinker with a spacer length of 7.4 Å. BMPS contains an amine reactive, NHS ester, and a maleimide group which is reactive towards sulfhydryl functional groups.
Hydroxylamine Hydrochloride (Hydroxylamine HCl) is a widely used reducing agent used in biomolecular applications. Hydroxylamine HCl is used for reducing EGS crosslinkers and deprotecting SATA protected proteins.
Succinimidyl 6-[3-(2-pyridyldithio)propionamido] hexanoate (LC-SPDP) is a heterobifunctional crosslinker that is amino reactive on one end and sulfhydryl reactive on the other end. LC-SPDP contains a long spacer arm (15.7 Å)for increased molecular flexibility and a reducible disulfide, which is allows for cleavage of the crosslinker after crosslink formation.