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EGS Crosslinker
Category: Homobifunctional Crosslinkers
Description
| Ethylene glycol bis(succininic acid) N-hydroxysuccinimide ester) is a cleavable, homobifuntional crosslinker that contains two NHS functional groups. The NHS functional groups of EGS are selectively reactive towards primary amines at pH 7 to 9. After crosslinking, the EGS spacer arm is cleavable with Hydroxylamine (CovaChem 11304) at pH 8.5. EGS is often used as a cleavable option when disulfide containing crosslinkers, such as DSP (CovaChem 13304
) and DTSSP (CovaChem 13303) are not an option due to the desire to retain disulfide networks of a protein intact.
Package Sizes: 100 mg and 1 gram Product Numbers: 13408-100 and 13408-1 Product Name: EGS Crosslinker Alternative Names: EGS; ethylene glycol bis(succinimidylsuccinate); ethylene glycol di(succinimidylsuccinate); ethylene glycoldisuccinate di(N-succinimidyl) ester; 70539-42-3; Di(N-succinimidyl) ethylene glycol disccuinate; C18H20N2O12
Specifications Appearance: White Solid Purity: is ≥ 90% by quantitative NMR Storage: 4 °C, protected from moisture
Properties Physical State: Solid CAS#: 70539-42-3 Chemical Formula: C18H20N2O12 Molecular Weight: 456.36 Spacer length: 16.1 Å Country of Origin: USA
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