2-Iminothiolane

  Description Price Buy
2-Iminothiolane
Package Sizes: 500 mg
SKU: 14104-500
WEIGHT: 0.20
$69.00
Add
2-Iminothiolane
Package Sizes: 1 gram
SKU: 14104-1
WEIGHT: 0.20
$126.00
Add

2-Iminothiolane hydrochloride (Traut's Reagent) is a useful reagent for converting primary amine functional groups into free sulfhydryl groups. Traut's reagent (2-IT) is a simple water soluble, ringed molecule that completes this primary amine (-NH2) to sulfhydryl (-SH) conversion reaction in a one-step procedure in the pH range of 7 to 10. Once modification of a protein molecule with 2-Iminothiolane is complete, free amine groups will have been irreversibly converted to a sulfhydryl group with a four atom chain and without significant disruption of the original amine groups protonation state.

After incorporation of the Traut's free sulfhydryl into a protein or otherwise, this -SH group makes for a very useful handle for further modification, such as selectively reacting this modified protein with a SMCC or BMPS containing conjugates, creating a permanent bond between two proteins. A 2-Iminothiolane modified protein or peptide could also be used to create a reversible link with an SPDP containing conjugate. Please feel free to contact our technical support staff for further questions specifically related to your application.

Package Sizes: 500 mg and 1 gram

Product Numbers: 14104-500mg and 14104-1g

Product Name: 2-Iminothiolane

Alternative Names: 2-IT; Traut's Reagent; 4781-83-3; 2-Iminothiolane HCl; 2-Iminothiolane hydrochloride; Dihydro-2-(3H)-thiophenimine hydrochloride; Dihydro-2-(3H)-thiophenimine HCl; C4H8ClNS

Specifications

Appearance: White Solid

Purity: is ≥ 90% by quantitative NMR

Storage: 4 °C, protected from moisture

 

Properties Physical State: Solid

CAS#: 4781-83-3

Chemical Formula: C4H8ClNS

Molecular Weight: 137.63

Spacer length: 8.1 Å

Melting Point: 198-201 °C (Lit)

Tariff Code: 2934.99.9000

  • BS2G Crosslinker

    BS2G (Sulfo-DSG) is a water soluble amine (amino) reactive homobifunctional crosslinker.
    $89.00
  • DCC (Dicyclohexylcarbodiimide)

    N,N''-Dicyclohexylcarbodiimide (DCC) is a zero length crosslinker. Dicyclohexylcarbodiimide is a coupling reagent used to couple carboxylic acids (COOH) to primary amines (-NH2).
    $19.00
  • DHB MALDI Matrix

    2,5-Dihydroxybenzoic acid (DHB) is a MALDI matrix used in the MALDI-MS of proteins, peptides, synthetic polymers, lipids and carbohydrates.
    $30.00
  • DST Crosslinker

    Disuccinimidyl tartrate (DST) is an amine reactive, water soluble, cleavable crosslinker. DST is a homobifunctional crosslinker that is reactive towards amines
    $119.00
  • EDC-HCL | EDAC-HCL | > 99%

    N-Ethyl-N'(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC-HCl) is a zero length protein crosslinker. Also known as EDAC-HCl, this reagent is often used with either Sulfo-NHS (CovaChem 13505) or NHS (CovaChem 13504). EDC functions by activating the carboxyl region of the protein or other molecule, and coupling it to an amine or other nucleophilic functional group.
    $19.00
  • GMBS Crosslinker

    4-Maleimidobutyric acid N-hydroxysuccinimide ester (GMBS) is a heterobifunctional crosslinker with a spacer length of 7.4 Å. BMPS contains an amine reactive, NHS ester, and a maleimide group which is reactive towards sulfhydryl functional groups.
    $142.00
  • HABA MALDI Matrix

    HABA MALDI Matrix
    $30.00
  • HPLC Grade Acetone

    CovaChem's HPLC Grade Acetone is a high purity solvent ideally suited for HPLC applications and general laboratory use.
    $76.00
*
*
*