2-Iminothiolane

  Description Price Buy
2-Iminothiolane
Package Sizes: 500 mg
SKU: 14104-500
WEIGHT: 0.20
$69.00
Add
2-Iminothiolane
Package Sizes: 1 gram
SKU: 14104-1
WEIGHT: 0.20
$126.00
Add

2-Iminothiolane hydrochloride (Traut's Reagent) is a useful reagent for converting primary amine functional groups into free sulfhydryl groups. Traut's reagent (2-IT) is a simple water soluble, ringed molecule that completes this primary amine (-NH2) to sulfhydryl (-SH) conversion reaction in a one-step procedure in the pH range of 7 to 10. Once modification of a protein molecule with 2-Iminothiolane is complete, free amine groups will have been irreversibly converted to a sulfhydryl group with a four atom chain and without significant disruption of the original amine groups protonation state.

After incorporation of the Traut's free sulfhydryl into a protein or otherwise, this -SH group makes for a very useful handle for further modification, such as selectively reacting this modified protein with a SMCC or BMPS containing conjugates, creating a permanent bond between two proteins. A 2-Iminothiolane modified protein or peptide could also be used to create a reversible link with an SPDP containing conjugate. Please feel free to contact our technical support staff for further questions specifically related to your application.

Package Sizes: 500 mg and 1 gram

Product Numbers: 14104-500mg and 14104-1g

Product Name: 2-Iminothiolane

Alternative Names: 2-IT; Traut's Reagent; 4781-83-3; 2-Iminothiolane HCl; 2-Iminothiolane hydrochloride; Dihydro-2-(3H)-thiophenimine hydrochloride; Dihydro-2-(3H)-thiophenimine HCl; C4H8ClNS

Specifications

Appearance: White Solid

Purity: is ≥ 90% by quantitative NMR

Storage: 4 °C, protected from moisture

 

Properties Physical State: Solid

CAS#: 4781-83-3

Chemical Formula: C4H8ClNS

Molecular Weight: 137.63

Spacer length: 8.1 Å

Melting Point: 198-201 °C (Lit)

Tariff Code: 2934.99.9000

  • Beta-Glucuronidase Powder

    Beta-Glucuronidase powder (β-Glucuronidase) is used in drug testing applications. With our low price of 250,000 units for ONLY &36;49, CovaChem is ready to become your preferred supplier of Beta-Glucuronidase.
    $49.00
  • BS3 Crosslinker

    Bis-sulfosuccinimidyl suberate (BS3) is an amino reactive, homobifunctional crosslinker. BS3 is water soluble and membrane impermeable.

    $89.00
  • DST Crosslinker

    Disuccinimidyl tartrate (DST) is an amine reactive, water soluble, cleavable crosslinker. DST is a homobifunctional crosslinker that is reactive towards amines
    $119.00
  • Hexafluoroisopropanol (HFIP)

    Hexafluoroisopropanol (HFIP) is also called 1,1,1,3,3,3-Hexafluoro-2-propanol or HFIP. HFIP is an acylation reagent that is used to introduce fluorine atoms into a compound and improve volatility. This is useful for Gas Chromatography (GC) applications and GCMS applications.
    $38.00
  • Hydroxylamine Hydrochloride

    Hydroxylamine Hydrochloride (Hydroxylamine HCl) is a widely used reducing agent used in biomolecular applications. Hydroxylamine HCl is used for reducing EGS crosslinkers and deprotecting SATA protected proteins.
    $19.00
  • LCMS Grade Water

    CovaChem's LCMS Grade water is refined for optimal performance in mass spectrometry applications.
    $39.00
  • Maleimide > 99%

    Maleimide (2,5-Pyrroledione) is a five member ringed compound that is commonly used in synthetic applications and as a synthetic starting material for cysteine blocking, Diels-Alder synthesis, and through Michael addition.
    $19.00
  • MBS Crosslinker

    MBS is a heterobifunction crosslinker that contains a maleimide group which is reactive towards sulfhydryls and an NHS ester, useful for targeting amine groups.
    $59.00
*
*
*