CovaChem's LCMS Grade Acetic Acid is ideally suited as a chromatography additive for use in both HPLC and LCMS applications. Acetic acid is typically beneficial as a separations enhancer, and has a weak ion pairing effect in the mass spectrometer, making dissociation of from the analytes relatively easy, often resulting in increased ionization efficiencies. CovaChem's LCMS Grade Acetic Acid comes in two convenient package sizes (10 x 1 mL Ampules and 25 mL bottles). The 1 mL Ampules of LCMS Grade Acetic Acid are useful for quickly preparing 1 Liter bottles of 0.1% Acetic Acid solutions in either water or other organic solvents.
Package Sizes: 10 x 1 mL and 25 mL
Product Numbers: 11201-10x1 or 11201-25
Product Name: LCMS Grade Acetic Acid
Alternative Names: LCMS Acetic Acid; Glacial Acetic Acid; Ethanoic Acid; Methanecarboxylic acid
Appearance: Clear liquid
Purity: is ≥ 99.8%
Storage: Room Temperature
Physical State: Liquid
CAS #: 64-19-7
Chemical Formula: C2H4O2
Molecular Weight: 60.05 amu
Boiling Point: 118-119 °C (Lit)
Density: 1.049 g/mL
Tariff Code: 2915.21.0000
Additional Product Information: LCMS Grade Acetic Acid Product Information Bulletin
N,O-bis-(trimethylsilyl) acetamide (BSA) is a silylation reagent used to form stable TMS derivatives that are volatile. BSA is used to derivatize carboxylic acids, phenols, steroids, amines, alcohols, and alkaloids.
Ethylene glycol bis(succininic acid) N-hydroxysuccinimide ester) is a cleavable, homobifuntional crosslinker that contains two NHS functional groups. The NHS functional groups of EGS are selectively reactive towards primary amines at pH 7 to 9. EGS is cleavable with hydroxylamine at pH 8.5. EGS is often used as a cleavable option when disulfide containing crosslinkers, such as DSP (CovaChem 13304) and DTSSP (CovaChem 13303) are not an option due to the desire to retain disulfide networks of a protein intact.
N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a silylation reagent, that donates a trimethylsilyl group to create thermally stable derivatives. MSTFA is reacts with a variety of polar molecules by replacing labile hydrogens. TMCS can be used in addition to MSTFA to form derivatives with hindered hydroxyl groups that won't ordinarily react with MSTFA, secondary amines, and amides.