Hexafluoroisopropanol (HFIP) is a reagent for acylation that is used to introduce fluorine atoms into a compound and improve a compounds volatility and detectability. Fluorine atoms on a GC analyte are widely utilized to increase the sensitivity of thermal conductivity detectors (TCD) due to their sensitivity towards halogens. Due to its high volatility and electronegative nature, Hexafluoroisopropanol has also found use in sample preparation for GCMS and other forms of gas chromatography. This acylation reagent is often used to acylate carboxylic acids that prove troublesome, due to their lack of volatility and their capacity for hydrogen bonding.
HFIP is also a useful solvent for many reactions, and for dissolving peptides and peptide reaction intermediates at increased concentrations.
Package Sizes: 10x1 g; 25 g; 100 g
Product Numbers: 12206-10x1, 12206-25 and 12206-100
Product Name: Hexafluoroisopropanol (HFIP)
Alternative Names: Hexafluoroisopropanol; HFIP; CAS 920-66-1; Hexafluoro-2-propanol; 1,1,1,3,3,3-Hexafluoro-2-propanol; C3F6H2O
Appearance: Clear, Colorless Liquid
Purity: is ≥ 99.6%
Storage: 20 °C, protected from moisture
Properties Physical State: Liquid
Chemical Formula: C3F6H2O
Molecular Weight: 168.04
Additional Product Information:
Hexafluoroisopropanol (HFIP) Product Information Bulletin
Hexafluoroisopropanol (HFIP) MSDS