CovaChem only offers reagents of the highest standards in the industry. Our chemical reagents are suitable for proteomics and other life science applications. These chemicals are refined beyond industry norms to ensure the successful utility in technically challenging applications.

CovaChem's chemical reagents are intended for use in life science, proteomics, as well as other sensitive analytical processes. Please inquire at for bulk pricing and availability of CovaChem's chemical reagents or other products.



2-Mercaptoethanol (2-ME) is a reducing agent used in synthetic and biological applications. This reducing agent is offered in multiple sizes to maximize its efficiency and shelf life. CovaChem's 2-Mercaptoethanol (11301-10 x 1 g) is designed for use in biological assays. These 1 gram hermetically sealed ampules provide maximum protection of the active thiol group and inconsistent activity from use to use or bottle to bottle.



4-Azidobenzoic acid

4-azidobenzoic acid is a heterobifunctional crosslinker that contains a carboxy group and a photoreactive phenyl azide group.



Citraconic Anhydride

Citraconic Anhydride (Methylmaleic anhydride) is used to block primary amine (-NH2) groups at pH 7 to 9. Citraconic anhydride reacts with primary amines to create a reversible amide linkage, which can be reversed under acidic conditions or in the presence of hydroxylamine.



DryBlend MES Buffered Saline, pH 4.7

MES buffered saline is ideally suited for protein cross linking reactions.



DryBlend PBS (Phosphate Buffered Saline), pH 7.2

Phosphate buffered saline is used as a buffer in protein crosslinking and protein modification reactions.



DTT-Clelands Reagent

Cleland's Reagent (DTT) is a reducing agent used to cleave disulfide bonds in proteins. This reagent is also useful for reducing the disulfide contained in DTSSP and DSP.



Hydroxylamine Hydrochloride

Hydroxylamine Hydrochloride (Hydroxylamine HCl) is a widely used reducing agent used in biomolecular applications. Hydroxylamine HCl is used for reducing EGS crosslinkers and deprotecting SATA protected proteins.



Maleimide > 99%

Maleimide (2,5-Pyrroledione) is a five member ringed compound that is commonly used in synthetic applications and as a synthetic starting material for cysteine blocking, Diels-Alder synthesis, and through Michael addition.



Molecular Biology Grade Glycine

Molecular Biology grade Glycine is frequently used as a component in biological buffers.



Molecular Biology Grade HEPES

HEPES is well suited as a buffer for many protein and cellular assays.



Molecular Biology Grade MES, Monohydrate

MES is a suitable buffer for many protein crosslinking reactions and other biological assays.




N-Ethoxycarbonylmaleimide is used in synthetic applications and in protein reactions. This compound can be used in reactions involving Diel-Alder reactions, Michael additions and can be utilized to introduce a maleimide group into a peptide or protein.



N-Ethylmaleimide (NEM)

N-ethylmaleimide (NEM) is a protein modifying chemical reagent used to protect or block sulfhydryl groups.




N-Methoxycarbonylmaleimide is a compound used in synthetic applications, including Diel-Alder reactions, and can be used to introduce a maleimide group onto a peptide or protein.




Tris(2-carboxyethyl) phosphine (TCEP) is a reducing agent that is frequently used to reduce disulfide bonds found between cysteine residues in proteins and in disulfide bonds found in proteins crosslinked with DTSSP (CovaChem 13304) or DSP (CovaChem 13303).



TMAH in Methanol (0.5 M)

TMAH in Methanol (0.5M); Trimethylphenylammonium Hydroxide Solution