Trifluoroacetic Acid (LCMS Grade TFA)

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Trifluoroacetic Acid (LCMS Grade TFA)
Package Size: 10 x 1 mL Ampules
SKU: 11204-10x1
WEIGHT: 0.20
$35.00
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Trifluoroacetic Acid (LCMS Grade TFA)
Package Size: 25 mL Bottle
SKU: 11204-25
WEIGHT: 0.20
$49.00
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Trifluoroacetic Acid (LCMS Grade TFA)
Package Size: 4 x 25 mL Bottles
SKU: 11204-4x25
WEIGHT: 0.20
$119.00
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CovaChem's LCMS Grade Trifluoroacetic acid (TFA) is well suited as a chromatography additive for difficult to separate analytes in HPLC and LCMS applications. CovaChem's LCMS TFA is an ideal additive for separations of peptides in peptide synthesis applications. TFA is widely used to separate both protected amino acid chains and deprotected peptides. Due to the amino and carboxylate groups having vastly different pka values, synthetic peptides can be particularly challenging to separate, The HPLC separation of peptides is much more easily achieved with 0.1% Trifluoroacetic acid being present in the mobile phase.

Trifluoroacetic acid (TFA) is typically beneficial as a separations enhancer, and is a moderately strong ion pairing agent, which can be a very effective way of gaining good analyte separation and obtaining sharp peaks in HPLC applications. Although TFA is and excellent low pH buffer for HPLC applications, this ion pairing effect has some negative impact on ionization efficiencies (compared to other acid additives, such as Formic acid (CovaChem 11202) and Acetic acid (CovaChem 11201. CovaChem offers several remedies for the impact of 0.1% TFA on ionization, in serving highly refined products that reverse this effect. This reduction of ionization efficiency can be overcome by incorporating a post-column addition of a “TFA fix” reagent, such as CovaChem's UltraPure (2-(2-methoxyethoxy) ethanol (CovaChem 11207) or LCMS Grade Propionic acid (CovaChem 11206). These products are easy to employ, and allow LCMS to be performed on peptides and proteins without altering HPLC methods that employ 0.1% TFA. These tfa fix reagents have saved countless hours of hplc method development and validation hours. Please feel free to contact our technical support for more information on this subject.

CovaChem's LCMS Grade TFA comes in two convenient package sizes (10 x 1 mL Ampules and 25 mL bottles). The 1 mL Ampules of LCMS Grade TFA are useful for quickly preparing 1 Liter bottles of 0.1% TFA solutions in either water or other organic solvents.

Product Name: LCMS Grade TFA
Alternative Names: LCMS TFA; LCMS TFA Amps; LCMS Grade TFA Amps; Trifluoroacetic acid; TFA Acid; CAS# 76-05-1; Perfluoric acid; 2,2,2-Trifluoroacetic acid; HPLC TFA; LCMS Grade TFA

Trifluoroacetic acid (CAS# 76-05-1) ampules for LCMS

Package Sizes: 10 x 1 mL and 25 mL
Product Numbers: 11204-10x1 or 11204-25

Specifications
Appearance: Clear liquid
Purity: is ≥ 99.5%
Storage: Room Temperature

Properties
Physical State: Liquid
CAS #: 76-05-1
Chemical Formula: C2HF2O2
Molecular Weight: 114.02 amu
pKa: 0.23
Boiling Point: 72.4 °C (Lit)
Density: 1.489 g/mL
Tariff Code: 2915.90.5000

Additional Product Information:
Trifluoroacetic Acid (TFA) Product Information Bulletin
Trifluoroacetic Acid (TFA) MSDS

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    N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a silylation reagent, that donates a trimethylsilyl group to create thermally stable derivatives. MSTFA is reacts with a variety of polar molecules by replacing labile hydrogens. TMCS can be used in addition to MSTFA to form derivatives with hindered hydroxyl groups that won't ordinarily react with MSTFA, secondary amines, and amides.
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