Chemicals


CovaChem only offers reagents of the highest standards in the industry. Our chemical reagents are suitable for proteomics and other life science applications. These chemicals are refined beyond industry norms to ensure the successful utility in technically challenging applications.

CovaChem's chemical reagents are intended for use in life science, proteomics, as well as other sensitive analytical processes. Please inquire at info@covachem.com for bulk pricing and availability of CovaChem's chemical reagents or other products.



  • 2-Mercaptoethanol

    2-Mercaptoethanol (2-ME) is a reducing agent used in synthetic and biological applications. This reducing agent is offered in multiple sizes to maximize its efficiency and shelf life. CovaChem's 2-Mercaptoethanol (11301-10x1g) is designed for use in biological assays. These 1 gram hermetically sealed ampules provide maximum protection of the active thiol group and inconsistent activity from use to use or bottle to bottle.

    Package Sizes: 10 x 1 g and 25 gram

    Product Numbers: 13301-10x1g and 13301-25g

    Product Name: 2-Mercaptoethanol

    Alternative Names: 2-Mercaptoethanol; beta-mercaptoethanol; b-mercaptoethanol; 2-ME; b-ME; 2-Hydroxy-1-ethanethiol; thioglycol; CAS# 60-24-2; C2H6SO

    Specifications

    Appearance: Clear liquid

    Purity: is ≥ 99%

    Storage: 4 °C, protected from light

     

    Properties Physical State: Liquid

    CAS#: 60-24-2

    Chemical Formula: C2H6SO

    Molecular Weight: 78.133

    $19.00
  • 4-Azidobenzoic acid

    p-Azidobenzoic acid is a chemical reagent that can be utilized to introduce a photoreactive (azide) group to a protein or other compound.

    Package Sizes: 1 gram and 5 grams

    Product Numbers: 14108-1 and 14108-5

    Product Name: 4-azidobenzoic acid

    Alternative Names: p-azidobenzoic acid; 4-ABA; HSAB acid

    Specifications

    Appearance: White Solid

    Purity: is ≥ 97%

    Storage: 4 °C, protected from light

     

    Properties Physical State: Solid

    CAS#: 6427-66-3

    Chemical Formula: C7H5N3O2S

    Molecular Weight: 163.13

    Tariff Code: 3824.90.9290

    $39.00
  • Citraconic Anhydride

    Citraconic Anhydride is a convenient, reversible amine blocking reagent. This protein modification reagent converts primary amines to amide groups with a terminal carboxylic acid moiety. Citraconic Anhydride reacts with primary amines, such as those found in lysine residues, at pH 7-9. This modification is conveniently reversed at pH 3, rendering a citraconic acid by-product. and returning the amine to its original composition. Alternatively, this reversal can be facilitated in the presence of Hydroxylamine (CovaChem 11304-25).

    Package Sizes: 25 grams and 100 grams

    Product Numbers: 14105-25 and 14105-100

    Product Name: Citraconic Anhydride

    Alternative Names: Citraconic anhydride; 2-Methylmaleic anhydride; CAS No. 616-02-4; C5H4O3

    Specifications

    Appearance: Clear Liquid

    Purity: is ≥ 98% by GC

    Storage: 20-25 °C, protected from moisture

    Properties Physical State: Liquid

    CAS#: 616-02-4

    Chemical Formula: C5H4O3

    Molecular Weight: 112.08

    Boiling Point: 213-214 °C (Lit)

    Melting Point: 6-10 °C (Lit)

    Density: 1.245 g/mL at 25 °C (Lit)

    Refractive Index: 1.47 - 1.472 at 20 °C (Lit)

    Tariff Code: 2917.19.7050

    IATA Code: 2810

    *Important Note: 100 gram size may ship as 4x25 grams to reduce shipping costs.

    $49.00
  • DryBlend MES Buffered Saline, pH 4.7

    MES Buffered Saline DryBlend pouches are optimally suited for protein conjugation reactions involving EDC or performing other protein conjugations. 2-(N-Morpholiino)ethanesulfonic acid monohydrate (MES Buffered Saline) is a buffer that does not contain carboxyl groups or reactive amines. This buffer is also optimized to render the appropriate pH range for EDC protein conjugations and other protein reactions.

    Each pouch is optimize to quickly and consistently prepare 100 mM MES Buffer with 0.9% Sodium Chloride, pH 4.7. Simply dissolve the contents in 500 mL of water, and the buffer is ready. No need to weigh out powdered buffers, or for pH adjustments. CovaChem's DryBlend pouches have made preparing conjugation buffer a breeze. These pouches allow for easy preparation of fresh buffer with each new assay. No more wondering if a buffer is fresh.

    Package Sizes: 10 pouches, 50 pouches and bulk quantities

    Product Numbers: 19214-10pk, 19214-50pk and 19214-custom

    Product Name: DryBlend MES Buffered Saline, pH 4.7

    Storage: Room Temperature


    $59.00
  • DryBlend PBS (Phosphate Buffered Saline), pH 7.2

    Phosphate Buffered Saline (PBS) DryBlend pouches are optimally suited for protein crosslinking and protein modification reactions. PBS is an amine free buffer with a pH of 7.2 used in numerous molecular biology and protein related assays. Each pouch is designed to quickly and consistently prepare 100 mM Sodium Phosphate and 0.15 M Sodium Chloride, pH 7.2.

    Simply dissolve the contents in 500 mL of water, and the PBS buffer is ready to use. There is no need to weigh out buffers or for tedious pH adjustments. CovaChem's DryBlend pouches have made preparing conjugation buffer simpler than ever. These pouches allow for easy preparation of fresh buffer right before use. No more wondering if a buffer is fresh.

    Package Sizes: 10 pouches, 50 pouches and bulk quantities

    Product Numbers: 19213-10pk, 19213-50pk and 19213-custom

    Product Name: DryBlend PBS (Phosphate Buffered Saline), pH 7.2

    Storage: Room Temperature


    $43.00
  • DTT-Clelands Reagent

    Cleland's Reagent (DTT) is a reducing agent used to cleave disulfide bonds in proteins. This reagent is also useful for reducing the disulfide contained in DTSSP and DSP.

    Package Sizes: 5 x 10 mg and 1 gram

    Product Numbers: 11302-5x10 and 11302-1g

    Product Name: DTT

    Alternative Names: Dithiothreitol; threo-1,4-Dimercapto-2,3-butanediol; Cleland’s reagent; 3483-12-3; C4H10O2 S2

    Specifications

    Appearance: White Solid

    Purity: is ≥ 99% (assay)

    Storage: 4 °C, protected from moisture

     

    Properties Physical State: Solid

    CAS#: 3483-12-3

    Tariff Code: 2930.90.9190

    Chemical Formula: C4H10O2 S2

    Molecular Weight: 154.25

    Melting Point: 41-44 °C

    $19.00
  • Hydroxylamine Hydrochloride

    Hydroxylamine hydrochloride is a reducing agent that is soluble in aqueous buffers. Hydroxylamine HCl is a reagent used in many biomolecular applications, including the cleavage of Glycine- Asparagine (Gly-Asn) in proteins and peptides.

    This chemical reagent is also recommended for the removal of the acetyl protecting group from N-succinimidyl S-acetylthioacetate (SATA, CovaChem 14102) modified proteins. CovaChem also carries protein crosslinkers, whose spacer arm can be cleaved by Hydroxylamine HCl, including EGS and Sulfo-EGS.

    Package Sizes: 25 grams

    Product Numbers: 13304-25

    Product Name: Hydroxylamine Hydrochloride

    Alternative Names: Hydroxylamine HCl; Hydroxylammonium chloride; 5470-11-1; NH2OH-HCl;

    Specifications

    Appearance: White Crystalline Solid

    Purity: is ≥ 99%

    Storage: Room Temperature, protected from moisture

    Properties

    Properties Physical State: Solid

    CAS#: 5470-11-1

    Chemical Formula: NH4OCl

    Molecular Weight: 69.49

    International Shipping

    Tariff Code: 2825.10.0000

    IATA (UN Code): 2923

    $19.00
  • Maleimide > 99%

    Maleimide (2,5-Pyrroledione) is compound with a wide range of synthetic and protein modification applications. 2,5-Pyrroledione is commonly utilized in synthetic applications and as a synthetic intermediate or starting material for numerous compounds. The double bond of Maleimide is reactive towards cysteines (-SH) and other thiol containing compounds. Maleimide (CAS# 541-59-3) can be used to block cysteine (-SH) residues, is useful in Diels-Alder reactions and Michael addition synthetic processes.

    CovaChem's chemists manufacture several Maleimide compounds, and knows first hand the importance of having this compound in a pure form. CovaChem's Maleimide is highly refined and is among the highest purity in the field, and is analyzed by gas chromatography with purity levels >99%. This product is competitively priced in our catalog sizes and in bulk format.

    Package Sizes: 5 grams and 25 grams (custom and bulk quantities also available)

    Product Numbers: 11306-5 and 11306-25

    Product Name: Maleimide >99%

    Alternative Names: 2,5-Pyrroledione; Maleimide


    Specifications

    Appearance: White Solid

    Purity: ≥ 99%

    Storage: 4 °C, protected from moisture


    Properties

    Properties Physical State: Solid

    CAS#: 541-59-3

    Tariff Code: 2925.19.9100

    UN Number (IATA): 2923

    Chemical Formula: C4H3NO2

    Molecular Weight: 97.07 g/mol

    Melting Point: 91-93 °C (Lit)


    Additional Product Information:
    Maleimide Product Information Bulletin
    $19.00
  • Molecular Biology Grade Glycine

    Glycine is an amino acid frequently used in the preparation of electrophoresis buffers and other biological buffers. CovaChem's Molecular Biology Glycine is also used to quench amine reactive cross linking reactions, such as protein crosslinking assays with BS3. Every batch of CovaChem's Molecular Biology Grade Glycine is lot tested for exceptionally high purity, with typical lot purity being higher than 99.8%.

    Package Sizes: 50 grams, 250 grams and bulk quantities

    Product Numbers: 19103-50, 19103-250 and 19103-custom

    Product Name: Glycine

    Product Grade: Molecular Biology Grade ≥ 99.5%

    Alternative Names: Aminoacetic acid; Glycocoll; Aminoethanoic acid; Glycine buffer; CAS# 56-40-6; C2H3NO2

    Storage: Room Temperature, Protected From Moisture


    Specifications

    Appearance: White Solid

    Purity: ≥ 99.5%

    Chlorides: 0.005% max

    Heavy Metals: 0.001%

    A260 nm: 0.02 max

    A280 nm: 0.02 max

    Solubility: To Pass Test

    Evaporative Residue: 0.1% max

    Sulfate: 0.005% max


    Properties

    Physical State: Solid

    CAS Number: 56-40-6

    Chemical Formula: C2H3NO2

    Molecular Weight: 75.07

    Tariff Code: 2922.49.4020

    $18.00
  • Molecular Biology Grade HEPES

    4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES) is a zwitterionic organic buffer used in cellular and molecular biology applications. CovaChem's buffers are refined to be the quality leader in the life science industry. Each lot is analyzed to be Protease free, DNase free and RNase free, and routinely have purity values of 99.8% or higher.

    HEPES is frequently employed in isoelectric focusing and cell culture applications. This buffer has a useful pH range of 6.8 to 8.2.

    Package Sizes: 25 grams, 250 grams and bulk quantities

    Product Numbers: 19102-25, 19102-250 and 19102-custom

    Product Name: HEPES

    Product Grade: Molecular Biology Grade

    Alternative Names: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid; 4-(2-Hydroxyethyl)piperazine-1-ethane-sulfonic acid; HEPES Free Acid; HEPES Buffer; C8H18N2O4S

    Tariff Code: 2933.59.9500

    Storage: Room Temperature, Protected From Moisture


    Specifications

    Appearance: White Crystalline Powder

    Purity: is ≥ 99.6%

    Heavy Metals: 10 ppm max;

    A260 nm: 0.050 max

    A280 nm: 0.050 max

    Solubility: To Pass Test

    Ignition Residue: 0.05% max

    Sulfate: 0.05% max


    Properties

    Physical State: Solid

    CAS Number: 7365-45-9

    Chemical Formula: C8H18N2O4S

    Molecular Weight: 283.30

    $18.00
  • Molecular Biology Grade MES, Monohydrate

    2-(N-Morpholiino)ethanesulfonic acid monohydrate (MES) is free of carboxyl groups and reactive amines. This buffer is frequently used in protein crosslinking procedures. CovaChem's buffers are refined to be the quality leader in the life science industry. Each lot is analyzed to be Protease free, DNase free and RNase free, and routinely have purity values of 99.8% or higher.

    MES is often used in protein coupling procedures involving EDC or similar carbodiimide crosslinking and conjugation reagents. This buffer are also frequently employed as an electrophoresis running buffer and as a buffer in plant or other biological assays where near neutral buffering capacity is required.

    Package Sizes: 25 grams, 250 grams and bulk quantities

    Product Numbers: 19101-25, 19101-250 and 19101-custom

    Product Name: MES Monohydrate

    Product Grade: Molecular Biology Grade

    Alternative Names: 2-(N-Morpholino)ethanesulfonic acid monohydrate; Good's buffer; 4-Morpholineethanesulfonic acid monohydrate; MES Hydrate; Morpholine-4-ethansulfonic acid; C6H13NO4S : H2O

    Storage: Room Temperature, Protected From Moisture


    Specifications

    Appearance: White Solid

    Purity: ≥ 99.6%

    IR: Conforms to Reference

    Chlorides: 0.005% max

    Heavy Metals: 1 ppm max

    A260 nm: 0.030 max

    A280 nm: 0.030 max

    Solubility: To Pass Test

    Ignition Residue: 0.05% max

    Sulfate: 0.05% max


    Properties

    Physical State: Solid

    CAS Number: 145224-94-8

    Chemical Formula: C6H13NO4S : H2O

    Molecular Weight: 213.25

    Tariff Code: 2934.99.9000

    Country of Origin: USA

    $18.00
  • N-Ethoxycarbonylmaleimide

    N-Ethoxycarbonyl maleimide (CAS# 55750-49-7) also known as N-Ethoxycarbonylmaleimide is used to introduce a maleimide group into the structure of a protein, peptide or amino acid. N-Ethoxycarbonylmaleimide can also be used to react with other amine containing compounds for the formation of a maleimide containing compound for later reactions with thiols (-SH). This compound is also useful for reactions involving Diel-Alder processes, Michael additions and other synthetic applications.
    $37.00
  • N-Ethylmaleimide (NEM)

    N-Ethylmaleimide (NEM) is a protein modifying chemical reagent used to protect sulfhydryl groups. N-Ethylmaleimide (NEM) is a useful reagent in protein research and in synthetic organic applications.
    $29.00
  • N-Methoxycarbonylmaleimide

    N-Methoxycarbonyl maleimide (CAS# 55750-48-6) also known as N-Methoxycarbonylmaleimide is a useful reagent for incorporating a a maleimide group into a protein, peptide, amino acid, or other amine containing molecule. N-Methoxycarbonyl maleimide is also used as a synthetic intermediate or starting material in reactions such as Diels-Alder and Michael additions.
    $39.00
  • TCEP-HCL

    TCEP Product Description

    Tris(2-carboxyethyl) phosphine (TCEP, also known as TCEP-HCL) is an odorless reducing agent frequently used to reduce cysteine-cysteine disulfide bonds in proteins and to reduce disulfide bonds in DTSSP (CovaChem 13304) or DSP (CovaChem 13303) crosslinked proteins. TCEP is also an excellent reagent of choice for the complete removal of disulfide containing biotinylation reagents, such as Sulfo-NHS-SS-Biotin (CovaChem 14207)

    TCEP is a potent and fast acting reducing agent, with effective sample reduction occurring in as little as 5 minutes at room temperature. This reagent is highly water soluble, can be used in a wide pH range (pH = 1.5-8.5), and is used in a variety of biological buffers. TCEP is compatible with most applications where disulfide reductions is required, and selectively reacts with S-S bonds, while remaining non-reactive towards other protein functional groups. TCEP usually does not need to be removed by desalting prior to further thiol (-SH) reactions, such as with Maleimide conjugation or reactions with Iodoacetyl reagents.

    Package Sizes: 1 gram, 5 grams, 25 grams, 100 grams

    Product Numbers: 11303-1, 11303-5, 11303-25, 11303-100

    Product Name: TCEP

    Alternative Names: TCEP; TCEP-HCl; TCEP Hydrochloride; Tris(2-carboxyethyl) phosphine HCl; CAS# 51805-45-9; C9H15O6P

    Specifications

    Appearance: White Solid

    Purity: is ≥ 99%

    Water Solubility: is ≥ 300 mg/mL

    Storage: 4 °C, protected from moisture

     

    Properties Physical State: Solid

    CAS#: 51805-45-9

    Chemical Formula: C9H15O6P

    Molecular Weight: 286.6


    Additional Product Information:
    TCEP HCl Product Information Bulletin
    TCEP HCl MSDS
    $29.00
  • TMAH in Methanol (0.5 M)

    TMAH in Methanol (0.5M) is an alkylation reagent used for derivatization.
    $35.00