Beta Glucuronidase


CovaChem supplies the highest grade Beta-Glucuronidase available for life science research and toxicology applications. Our β-Glucuronidase is extremely active, and available as a lyophilized powder and as an auto-sampler compatible, low viscosity solution.

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CovaChem's Beta-Glucuronidase is isolated and purified from farm-raised Red Abalone. Our sourcing of Abalone is done in an environmentally friendly way, and is always derived from high quality farms, rather than from wild sources. This ensures that our source is stable and consistent, and will not deplete our oceans of these important organisms.

Abalone is known to be a superior source of this enzyme for the cleavage of drug-glucuronide conjugates in serum or urine drug testing applications. Abalone derived Beta-Glucuronidase consistently performs better than other sources of this enzyme, including: Helix Pomatia, Patella Vulgate, Bovine Liver, and E. Coli.

CovaChem's Beta-Glucuronidase has proven to be more temperature stable than many other forms of this enzyme. Studies have confirmed that our enzyme performs well in cleavage assays at temperatures as high as 65 °C!


Beta Glucuronidase Mechanism

R=opiod or other xenobiotic

Figure: β-Glucuronidase Reaction for the Hydrolysis of Drug-Glucuronide Conjugates


CovaChem's β-Glucuronidase is specifically optimized for drug screening applications, and proven to deliver exceptional hydrolysis efficiencies of a wide range of drug conjugates. See our product pages to learn more about CovaChem's Beta Glucuronidase Powder and our highly active Beta Glucuronidase Solution.


Beta Glucuronidase Promotion Details*
Pay for Ground Shipping at checkout, and CovaChem will automatically upgrade shipping to FedEx Priority Overnight for free!

  • Offer Valid for Limited Time Only
  • Not applicable with any other discounts or offers
  • Applies only to Beta-Glucuronidase shipping (not other products)
  • Offer applies only to US Customers (Lower 48 States)
  • Beta-Glucuronidase Powder

    Beta-Glucuronidase Powder (β-Glucuronidase), which is derived from Abalone (Molluskan Source), is used by toxicologists to detect a variety of drug metabolites (ie. opiods, steroids, cannabinoids, benzodiazipines, etc.) in urine, plasma, and other biological fluids. Beta-Glucuronidase functions by enzymatically hydrolyzing glucoronides prior to analysis by LCMS, immunoassay, mass spectrometry, GCMS or other methods. CovaChem's Beta-Glucuronidase is prepared to provide exceptionally high activity to allow complete hydrolysis of glucuronide conjugates.

    CovaChem's Beta-Glucuronidase lyophilized powder is highly active and easily dissolves in water. This enzyme is also available as a (β-Glucuronidase solution).

    Promotion: Free Shipping Upgrade on Beta Glucuronidase (Details below)*

    Package Sizes: 250,000 units, 500,000 units, 1,000,000 units and 2,000,000 units

    Product Numbers: 20102-250, 20102-500, 20102-1 and 20102-2

    Product Name: Beta-Glucuronidase Powder

    Alternative Names: β-Glucuronidase; β-D-Glucuronide; glucuronosohydrolase; Beta-Gluc

    Specifications

    Appearance: Tan Lyophilized Powder

    Identity Test: To Pass

    Glucuronidase Activity: 1,000,000 - 2,000,000 Units/gram
    Note: One unit will liberate 1.0 μg phenolphthalein from phenolphthalein glucuronide per hour at 37 ⁰C at pH 5.0.

    Sulfatase Activity: 100,000 - 200,000 Units/gram
    Note: One Sulfatase unit will hydrolyze 1.0 µmole p-nitrocatechol sulfate per hour at 37 ⁰C at pH 5.0.

    Other Properties

    CAS#: 9001-45-0

    Country of Origin: USA

    Tariff Code: 3507.90.7000

    Recommended Storage: -20 °C

    Optimal pH
    Glucoronidase Activity: 4.5 to 5.0
    Sulfatase Activity: 6.2

    Additional Product Information:
    Beta Glucuronidase Powder Product Information Bulletin

    Beta Glucuronidase Promotion Details*
    Pay for Ground Shipping at checkout, and CovaChem will automatically upgrade shipping to FedEx Priority Overnight for free!

    • Offer Valid for Limited Time Only
    • Not applicable with any other discounts or offers
    • Applies only to Beta-Glucuronidase shipping (not other products)
    • Offer applies only to US Customers (Lower 48 States)
    $49.00
  • Beta-Glucuronidase Solution

    Beta-Glucuronidase (β-Glucuronidase), derived from Abalone (Molluskan Source), is often used by toxicology laboratories to detect a variety of drug metabolites (ie. opiods, steroids, cannabinoids, benzodiazipines, etc.) in urine, plasma, and other biological fluids. Beta-Glucuronidase functions by enzymatically hydrolyzing glucoronides prior to their analysis by immunoassay, LCMS, mass spectrometry, GCMS or other means. CovaChem's β-Glucuronidase is prepared to provide optimal hydrolysis of Glucuroconjugates in urine samples.

    CovaChem's Beta-Glucuronidase low odor solution is highly active, and is lower in viscosity, allowing it to be easily compatible with autosampler delivery. This enzyme is also available as a ( lyophilized powder ).

    Promotion: Free Shipping Upgrade on Beta Glucuronidase (Details below)*

    Package Sizes: 5 mL, 10 mL, 25 mL and 50 mL

    Product Numbers: 20101-5, 20101-10, 20101-25 and 20101-50

    Product Name: Beta-Glucuronidase Solution

    Alternative Names: β-Glucuronidase; β-D-Glucuronide; glucuronosohydrolase; Beta-Gluc

    Specifications

    Appearance: Dark Amber Liquid

    Identity Test: To Pass

    Glucuronidase Activity: > 100,000 units/mL
    Note: One unit will liberate 1.0 μg phenolphthalein from phenolphthalein glucuronide per hour at 37 ⁰C at pH 5.0.

    Other Properties

    CAS#: 9001-45-0

    Country of Origin: USA

    Tariff Code: 3507.90.7000

    Recommended Storage: 4 °C

    Optimal pH
    Glucoronidase Activity: 4.5 to 5.0
    Sulfatase Activity: 6.2

    Beta Glucuronidase Promotion Details*
    Pay for Ground Shipping at checkout, and CovaChem will automatically upgrade shipping to FedEx Priority Overnight for free!

    • Offer Valid for Limited Time Only
    • Not applicable with any other discounts or offers
    • Applies only to Beta-Glucuronidase shipping (not other products)
    • Offer applies only to US Customers (Lower 48 States)
    $75.00