Acylation

  • 4-carbethoxyhexafluorobutyrl chloride (4-CB)

    4-carbethoxyhexafluorobutyrl chloride (4-CB) is an alkylation reagent used to derivatize samples for improved gas chromatographic separations. 4-CB can be used to derivatize amphetamine metabolites in blood samples prior to GC analysis.

    Package Sizes: 5 x 1 gram and 25 grams

    Product Numbers: 12207-5x1 and 12207-25

    Product Name: 4-carbethoxyhexafluorobutyrl chloride (4-CB)

    Alternative Names: 4-carbethoxyhexafluorobutyrl chloride; 4-CB

    Specifications

    Appearance: Clear, colorless liquid

    Purity: is ≥ 99%

    Storage: 4 °C, protected from moisture

    Properties Physical State: Liquid

    CAS#: 18381-53-8

    Chemical Formula: C7H7ClF6O2

    Molecular Weight: 223.08

    Boiling Point: 159 °C (Lit)

    Specific Gravity: 1.596 (Lit)

    $99.00
  • Heptafluorobutyric anhydride |HFAA | CAS 336-59-4 | HFBA Anhydride

    Heptafluorobutyric anhydride (HFAA) is a acylation reagent and protecting group often used to acylate amines, alcohols, and phenols. HFAA is used to increase volatility of an analyte, and to introduce fluorine atoms for better detection limits in gas chromatography applications.

    Package Sizes: 10x1 g; 25 g; 100 g

    Product Numbers: 12203-10x1, 12203-25 and 12203-100

    Product Name: Heptafluorobutyric anhydride (HFAA)

    Alternative Names: Heptafluorobutyric anhydride; HFAA; CAS 336-59-4; HFBA Anhydride; Heptafluorobutyric acid anhydride; buy HFAA; HFAA anhydride; C8F14O3

    Specifications

    Appearance: Clear, Colorless Liquid

    Purity: is ≥ 98%

    Storage: 20 °C, protected from moisture

     

    Properties Physical State: Liquid

    CAS#: 336-59-4

    Chemical Formula: C8F14O3

    Molecular Weight: 410.06

    $42.00
  • Hexafluoroisopropanol (HFIP)

    Hexafluoroisopropanol (HFIP) is a reagent for acylation that is used to introduce fluorine atoms into a compound and improve a compounds volatility and detectability. Fluorine atoms on a GC analyte are widely utilized to increase the sensitivity of thermal conductivity detectors (TCD) due to their sensitivity towards halogens. Due to its high volatility and electronegative nature, Hexafluoroisopropanol has also found use in sample preparation for GCMS and other forms of gas chromatography. This acylation reagent is often used to acylate carboxylic acids that prove troublesome, due to their lack of volatility and their capacity for hydrogen bonding. HFIP is also a useful solvent for many reactions, and for dissolving peptides and peptide reaction intermediates at increased concentrations.


    Package Sizes: 10x1 g; 25 g; 100 g

    Product Numbers: 12206-10x1, 12206-25 and 12206-100

    Product Name: Hexafluoroisopropanol (HFIP)

    Alternative Names: Hexafluoroisopropanol; HFIP; CAS 920-66-1; Hexafluoro-2-propanol; 1,1,1,3,3,3-Hexafluoro-2-propanol; C3F6H2O

    Specifications

    Appearance: Clear, Colorless Liquid

    Purity: is ≥ 99.6%

    Storage: 20 °C, protected from moisture

     

    Properties Physical State: Liquid

    CAS#: 920-66-1

    Chemical Formula: C3F6H2O

    Molecular Weight: 168.04

    Additional Product Information:
    Hexafluoroisopropanol (HFIP) Product Information Bulletin
    Hexafluoroisopropanol (HFIP) MSDS

    $38.00
  • N-Methyl-bis-trifluoroacetamide (MBTFA)

    N-Methyl-bis(trifluoroacetamide), MBTFA is a member of the perfluoroacid anhydride family of products. MBTFA is reactive towards primary (-NH2) and secondary amines (-NRH), hydroxyl (-OH) and thiol (-SH) groups under mild and non-acidic conditions. The product derivatives and the reaction bi-products of MBTFA are volatile and stable, making it a good choice for trifluoroacetylating reagent.

    Under standardized conditions, MBTFA reacts faster with amines than with alcohols, phenols or thiols. This reagent is commonly used to derivatize carbohydrates, creating volatile derivatives that are easy to analyze. Like other fluorinated acetylation reagents, MBTFA derivatives are detected by electron capture detectors (ECD) with great sensitivity.

    Package Sizes: 10x1 gram 25 grams and 100 grams

    Product Numbers: 12204-10x1, 12204-25, and 12204-100

    Product Name: MBTFA

    Alternative Names: N-Methyltrifluoroacetamide; N-Methyl-bis(trifluoroacetamide); MBTFA derivatization; 2,2,2-Trifluoro-N-methyl-N-trifluoroacetamide, 2,2,2-Trifluoro-N-methyl-N-trifluoroacetyl acetamide; CAS# 685-27-8

    Specifications

    Appearance: Clear, colorless liquid

    Purity: is ≥ 98.0%

    Storage: 20 °C, protected from moisture

    Properties

    Properties Physical State: Liquid

    CAS#: 685-27-8

    Chemical Formula: C5H3F6NO2

    Molecular Weight: 223.07

    Boiling Point: 123 – 124 °C (Lit)

    Specific Gravity: 1.547 (Lit)

    International Shipping

    Tariff Code: 2925.19.9100

    IATA (UN Code): 2920

    $36.00
  • Pentafluoropropionic alcohol | PFPOH | CAS 422-05-09 | 2,2,3,3,3-Pentafluoro-1-propanol

    Pentafluoropropionic alcohol (PFPOH) is a protecting group and an acylation reagent commonly employed to acylate amines, alcohols, and phenols. PFPOH is used to increase volatility of an analyte, and to introduce fluorine atoms for better detection limits in gas chromatography applicaitons.

    Package Sizes: 10x1 g; 25 g; 100 g

    Product Numbers: 12205-10x1, 12205-25 and 12205-100

    Product Name: 2,2,3,3,3-Pentafluoro-1-propanol (PFPOH)

    Alternative Names: PFPOH; Pentafluoropropionic alcohol; Pentafluoropropanol; CAS 422-05-09; C3F5H3O

    Specifications

    Appearance: Clear, Colorless Liquid

    Purity: is ≥ 99.0%

    Storage: 20 °C, protected from moisture

     

    Properties Physical State: Liquid

    CAS#: 422-05-09

    Chemical Formula: C3F5H3O

    Molecular Weight: 150.05

    $42.00
  • Pentafluoropropionic anhydride | PFAA | PFPA | CAS 356-42-3

    Pentafluoropropionic anhydride (CAS# 356-42-3) is an acylation reagent and protection reagent used to acylate amines, alcohols, and phenols. Pentafluoropropionic acid anhydride (PFAA) is used to introduce fluorine atoms into a molecule and to improve performance in gas chromatography applicaitons.

    Package Sizes: 10x1 g; 25 g; 100 g

    Product Numbers: 12202-10x1, 12202-25 and 12202-100

    Product Name: PFAA

    Alternative Names: PFAA; Pentafluoropropionic anhydride; Pentafluoropropionic acid anhydride; CAS 356-42-3; PFPA C6F10O3

    Specifications

    Appearance: Clear, Colorless Liquid

    Purity: is ≥ 99%

    Storage: 20 °C, protected from moisture

     

    Properties Physical State: Liquid

    CAS#: 356-42-3

    Chemical Formula: C6F10O3

    Molecular Weight: 310.05

    $42.00
  • Trifluoroacetic anhydride (CAS# 407-25-0)

    Trifluoroacetic anhydride (CAS# 407-25-0) is an acylation reagent and protection reagent. TFAA is reactive towards amines, alcohols and phenol functional groups. As a GC derivatization reagent, TFAA derivatives are often introduced for the sake of improving gas chromatographic resolution and improved detection with ECD detectors.

    The reaction between trifluoroacetic acid anhydride (TFAA) and compounds containing amines or alcohol moieties is facile and the reaction is easy to conduct. After the preparation of O-trifluoroacetyl and N-trifluoroacetyl derivatives, gas chromatograms tend to be significantly improved due to decreased analyte polarity and increased sample volatility. TFAA is one of CovaChem's signature products, and is among the highest purity in the industry. Inquire for bulk quantities of this high quality trifluoroacetic anhydride.

    Package Sizes: 10x1 g; 25 g; 100 g

    Product Numbers: 12201-10x1, 12201-25 and 12201-100

    Product Name: TFAA

    Alternative Names: TFAA; Trifluoroacetic anhydride; C4F6O3

    Specifications

    Appearance: Clear, Colorless Liquid

    Purity: is ≥ 99.0%

    Storage: 20 °C, protected from moisture

    Properties

    Properties Physical State: Liquid

    CAS#: 407-25-0

    Chemical Formula: C4F6O3

    Molecular Weight: 210.03

    Boiling Point: 39.5-40 °C (Lit)

    Melting Point: -65 °C (Lit)

    Density: 1.487

    Country of Origin: USA

    Tariff Code: 2915.90.5000


    Additional Product Information:
    Trifluoroacetic Anhydride (TFAA) Protocol and Product Information Bulletin
    Trifluoroacetic Anhydride (TFAA) MSDS
    $38.00